Joint / multimodal sequence–structure generation
Практический сценарий
Нужно coupled generation sequence и structure, возможно с function prompts.
Вход
- partial sequence/structure/function prompts
Pipeline diagram
Multimodal generation
→Model confidence
→Independent validation
Mermaid diagram
flowchart TD
A[Partial multimodal prompt] --> B[Joint generator]
B --> C[Sequence-structure pair]
C --> D[Internal confidence]
D --> E[Independent folding and assays]Стадии pipeline
| Стадия | Архитектурный класс | Что происходит | Генерация или оценка | Generator | Промежуточный объект | Альтернативы |
|---|---|---|---|---|---|---|
| Multimodal generation | Masked multimodal LM or diffusion | Co-generation tracks | generation | esm3 | Sequence–structure pairs | Chroma, ProteinGenerator |
| Model confidence | Internal likelihood/confidence | In-loop ranking | evaluation | NR | Ranked pairs | NR |
| Independent validation | External predictor + assays | Проверка вне модели | external_evaluation | NR | Shortlist | AlphaFold2 / ColabFold |
Hardware и runtime
Large multimodal models may be API-gated. ESM3 small model non-commercial. Exact runtime NR.
Evidence level
ESM3/Chroma/ProteinGenerator have prospective general-protein examples, not antibody-specific.
Точки отказа
- License/API limits.
- Confidence as function.
- Antibody claims without evidence.
Критерии решения
- Legal review of weights?
- Need antibody evidence? Choose another workflow.