Generalized biomolecular modeling and design with sequence-space diffusion
Peer-reviewed| Поле | Значение |
|---|---|
| Authors | NR |
| Year | 2025 |
| Venue / status | Peer-reviewed journal; Nature Biotechnology (Q1) |
| DOI | 10.1038/s41587-024-02395-w |
| URL | https://doi.org/10.1038/s41587-024-02395-w |
| Preprint URL | NR |
| Tools | ProteinGenerator |
Задача и claimed novelty
| Поле | Значение |
|---|---|
| Main biological task | Sequence-space diffusion for joint sequence/structure and multistate functional design |
| Claimed novelty | NR |
Архитектура
| Поле | Значение |
|---|---|
| Model architecture | RoseTTAFold sequence-space diffusion with structural refinement and guidance potentials |
| Input representation | NR |
| Encoder / decoder | NR |
| Generative state | Coupled sequence–structure proposals |
| Conditioning | Sequence/structure motifs, DSSP/hotspots, multistate potentials |
| Sampling | NR |
Training
| Поле | Значение |
|---|---|
| Objectives / losses | NR |
| Dataset | NR |
| Preprocessing | NR |
Inference
NR
Baselines и retrospective benchmarks
| Поле | Значение |
|---|---|
| Baselines | NR |
| Retrospective | NR |
Prospective experimental validation
| Поле | Значение |
|---|---|
| Prospective | Prospective general protein evidence |
| Tested designs | Multiple multistate/functional designs; exact aggregate: NR |
| Success criterion | Prospective general protein evidence |
| Main results | Prospective general protein evidence |
Limitations
RoseTTAFold-derived confidence is not independent validation; environment is nontrivial; no antibody-specific proof.
Что статья показывает
- Prospective general protein evidence
Чего статья не показывает
- Predicted confidence, likelihood, pLDDT, docking or developability scores are not experimental affinity.
Размеченные утверждения
| Утверждение | Тип | Локатор |
|---|---|---|
| Generalized biomolecular modeling and design with sequence-space diffusion | Interpretation | DOI/URL from landscape matrix |
| Publication status: Peer-reviewed journal; Nature Biotechnology (Q1) | Author-reported | landscape matrix, publication status column |
Review queue
- Bibliographic title must be verified against the PDF.
Source-grounded разбор статьи
Исследовательский вопрос
[MATRIX]Sequence-space diffusion for joint sequence/structure and multistate functional design
Утверждения и поддержка evidence
[MATRIX]Claimed novelty: NR
[INTERPRETATION]Статья не «доказывает» общее преимущество метода вне своего экспериментального дизайна.
Что представленный evidence не поддерживает
- Predicted confidence, likelihood, pLDDT, docking or developability scores are not experimental affinity.
Ограничения, признанные авторами
[MATRIX]RoseTTAFold-derived confidence is not independent validation; environment is nontrivial; no antibody-specific proof.
Дополнительные ограничения интерпретации
NRПока Methods/SI не прочитаны, нельзя утверждать split leakage, точные гиперпараметры и полноту ablation.