BoltzGen: universal binder design
Preprint| Поле | Значение |
|---|---|
| Authors | NR |
| Year | 2025 |
| Venue / status | bioRxiv preprint (Frontier/Watchlist) |
| DOI | 10.1101/2025.11.20.689494 |
| URL | https://doi.org/10.1101/2025.11.20.689494 |
| Preprint URL | https://doi.org/10.1101/2025.11.20.689494 |
| Tools | BoltzGen |
Задача и claimed novelty
| Поле | Значение |
|---|---|
| Main biological task | All-atom universal binder generation across proteins, peptides and nanobodies |
| Claimed novelty | NR |
Архитектура
| Поле | Значение |
|---|---|
| Model architecture | All-atom generative diffusion unified with folding; design specification language |
| Input representation | NR |
| Encoder / decoder | NR |
| Generative state | Binder sequence–structure and target complex |
| Conditioning | Residue/chain masks, modality, target context, geometry; supports diverse biomolecules |
| Sampling | NR |
Training
| Поле | Значение |
|---|---|
| Objectives / losses | NR |
| Dataset | NR |
| Preprocessing | NR |
Inference
NR
Baselines и retrospective benchmarks
| Поле | Значение |
|---|---|
| Baselines | NR |
| Retrospective | NR |
Prospective experimental validation
| Поле | Значение |
|---|---|
| Prospective | Includes nanobody and live-cell/functional examples; still preprint |
| Tested designs | Distributed multi-lab campaigns across modalities; per-task counts in preprint |
| Success criterion | Includes nanobody and live-cell/functional examples; still preprint |
| Main results | Includes nanobody and live-cell/functional examples; still preprint |
Limitations
Preprint; unified model scores are not independent validation; evidence differs greatly by binder modality.
Что статья показывает
- Includes nanobody and live-cell/functional examples; still preprint
Чего статья не показывает
- Predicted confidence, likelihood, pLDDT, docking or developability scores are not experimental affinity.
Размеченные утверждения
| Утверждение | Тип | Локатор |
|---|---|---|
| BoltzGen: universal binder design | Interpretation | DOI/URL from landscape matrix |
| Publication status: bioRxiv preprint (Frontier/Watchlist) | Author-reported | landscape matrix, publication status column |
Review queue
- Bibliographic title must be verified against the PDF.
Source-grounded разбор статьи
Исследовательский вопрос
[MATRIX]All-atom universal binder generation across proteins, peptides and nanobodies
Утверждения и поддержка evidence
[MATRIX]Claimed novelty: NR
[INTERPRETATION]Статья не «доказывает» общее преимущество метода вне своего экспериментального дизайна.
Что представленный evidence не поддерживает
- Predicted confidence, likelihood, pLDDT, docking or developability scores are not experimental affinity.
Ограничения, признанные авторами
[MATRIX]Preprint; unified model scores are not independent validation; evidence differs greatly by binder modality.
Дополнительные ограничения интерпретации
NRПока Methods/SI не прочитаны, нельзя утверждать split leakage, точные гиперпараметры и полноту ablation.